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Calculation of Anisotropy and Symmetry Coefficients of Corneal Nerve Orientation Based on Automated Recognition of Digital Confocal Images

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Biomedical Engineering Aims and scope

A new principle of morphometric description of corneal nerves that can be used for diagnosing several systemic neuropathies and as a criterion of the state of local corneal innervation is described. The new principle satisfies the following conditions: objectivity, independence on the method of confocal imaging of the neural network, tolerance to conditions of local illumination and transparency of the media, as well as minimum dependence on the choice of confocal imaging point within the cornea. All measurements were completely automated. Based on these measurements, Liner 1.1 software was developed. The analysis of images obtained by Confoscan 4 (Nidec) and HRT III instruments with a special corneal module proved functionality of the technique. Additionally, it was found that despite statistical similarity of the results and principle possibility to use the Confoscan 4 for image analysis, the HRT III provides better resolution and correspondingly greater completeness of analysis.

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Authors and Affiliations

  1. Helmholtz Research Institute of Eye Diseases, Russian Academy of Medical Sciences, Moscow, Russia

    S. Je. Avetisov, I. A. Novikov, S. S. Mahotin & Z. V. Surnina

  2. Sechenov First Moscow State Medical University, Moscow, Russia

    S. Je. Avetisov & Z. V. Surnina

Authors
  1. S. Je. Avetisov
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  2. I. A. Novikov
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  3. S. S. Mahotin
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  4. Z. V. Surnina
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Corresponding author

Correspondence to S. Je. Avetisov.

Additional information

Translated from Meditsinskaya Tekhnika, Vol. 49, No. 3, May-Jun., 2015, pp. 23-25.

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Avetisov, S.J., Novikov, I.A., Mahotin, S.S. et al. Calculation of Anisotropy and Symmetry Coefficients of Corneal Nerve Orientation Based on Automated Recognition of Digital Confocal Images. Biomed Eng 49, 155–159 (2015). https://doi.org/10.1007/s10527-015-9519-5

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  • DOI: https://doi.org/10.1007/s10527-015-9519-5

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